Synthesis of Chiral Diazapyridino-18-Crown-6 Ligands.
Abstract
New chiral diazapyridino-18-crown-6 macrocycles 1-5 (Figure 1) have been prepared. Cyclization of chiral diols 6-10 containing two methyl or two benzyl substituents or both two methyl and two phenyl substituents with 2,6-pyridinedimethyl ditosylate in the presence of sodium hydride gave the symmetrical macrocyclic ligands 1-5. 1-5 have three equally spaced nitrogen atoms in the ring which should form ideal tripod hydrogen bonds with chiral organic ammonium salts.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 09, 1996
- Accession Number
- ADA309193
Entities
People
- Jerald S. Bradshaw
- Reed Izatt
- Tingmin Wang
Organizations
- Brigham Young University