Synthesis of Chiral Pyridine-Based Macrobicyclic Clefts.
Abstract
An achiral (3) and two chiral pyridine-based macrobicyclic clefts (4 and 5) have been prepared by treating 2,6-bis(2',6'-bis(bromomethyl)-4'- methylphenoxymethyl)pyridine (2) with the appropriate achiral and chiral glycols. Starting 2 was prepared by first treating 2,6- bis(hydroxymethyl)-4-methylphenol with 2,6-pyridinedimethyl ditosylate followed by phosphorus tribromide.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1996
- Accession Number
- ADA309257
Entities
People
- Jerald S. Bradshaw
- Paul C. Hellier
- Reed Izatt
Organizations
- Brigham Young University