Chiral Pyridine-Based Macrobicyclic Clefts: Enantiomeric Recognition of Chiral Organic Ammonium Salts.
Abstract
Achiral macrobicyclic cleft containing a pyridine ring (1) formed a complex at 25 deg C in 50% CH3OH/50% CHCl3(v/v), with a primary ammonium salt (log K= 3.15) as evidenced by a significant change in the (1)H NMR spectrum. Highly organized pyridine-containing macrobicycle (S,S,S,S)-2 exhibited recognition at 25 deg C in 20% C2H5OH/80% 1,2-C2H4Cl2 (v/v) for the (S) enantiomer of alpha- (1-naphthyl)ethylammonium perchlorate (NapEt) over its (R) form (delta log K= 0.85). This high recognition factor probably reflects an increase in molecular rigidity by the introduction of a second macroring on the monocyclic pyridinocrown ligand.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1996
- Accession Number
- ADA309259
Entities
People
- J. J. Young
- Jerald S. Bradshaw
- Paul C. Heller
- Reed Izatt
- Xian X. Zhang
Organizations
- Brigham Young University