Dose-Response Correlation of Methadone and its Metabolite EDDP in Human Hair. Completion of the Second and Preparation of the Third Test Series.
Abstract
Analogous to the first test series, the following steps were undertaken with each of the subjects of the Methadone distribution center in Saarbruecken: (a) Five sweat patches were applied and then removed after one, two, three, four, and six days respectively. Contrary to the patients of Dr. Franta's practice, none of the subjects complained about allergic reactions or irritations. Yet, several of the sweat patches were lost, and a few subjects commented on poor adhesion of the patches to their skin. (b) One strand of hair was bleached and simultaneously, another unbleached strand was removed as a reference. The bleaching procedure was performed with a conventional hair bleaching - - agent over a distance of at least 1 cm from the scalp. The bleaching agent was kept on the hair strand for 45 minutes and was then washed out with shampoo. (c) After four weeks the bleached hair strand as well as an unbleached agent was kept on the hair strand (for reference) were removed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1995
- Accession Number
- ADA309899
Entities
Organizations
- United States Naval Research Laboratory