Sol-Gel Based Electrochemical Biosensors.
Abstract
This work is based on the use of the sol-gel process to encapsulate biomolecules in a porous silicate matrix. The porosity of the matrix is such that small molecules and ions can readily diffuse into the materials while the much larger proteins remain trapped in the silicate network. Using this approach, it is possible to develop new types of solid state sensors which use the specificity of enzymes and proteins for binding of substrates or related molecules. The objective of our initial work has been to obtain electron transport from the redox center of an encapsulated enzyme (making use of redox-active molecules or mediators) so as to measure the electrochemical response of the doped sol-gel to an external analyte.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 18, 1996
- Accession Number
- ADA310507
Entities
People
- B. C. Dave
- Bruce S. Dunn
- J. I. Zink
- J. S. Valentine
Organizations
- University of California, Los Angeles