Role of Accessory Molecule in Endotoxin-Endothelial Interactions and Endothelial Barrier Dysfunction.

Abstract

This grant has been renegotiated and the new technical objectives are: (1) To determine whether LPS induces tyrosine phosphorylation of endothelial cell proteins that can be coupled to changes in barrier function. (2) To determine whether this LPS-induced endothelial intercellular gap formation and barrier dysfunction is due to zonula adherens and/or focal adhesion disassembly. (3) To determine which protein substrates are the targets of LPS-induced tyrosine phosphorylation.

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Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1995
Accession Number
ADA312047

Entities

People

  • Simeone E. Goldblum

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical And Dental Materials
  • Cell Membrane Structures
  • Cells
  • Chemistry
  • Disassembly
  • Dysfunction
  • Endothelial Cells
  • Endotoxins
  • Inhibition
  • Materials
  • Molecular Dynamics
  • Molecules
  • Phosphorylation
  • Polymeric Films
  • Proteins
  • Tyrosine

Readers

  • Immunology and Pathology
  • Molecular Biology and Genetics