A Follow-up of a National Cohort of Breast Disease - Factors Affecting the Development of Breast Cancer.
Abstract
In 1979-80 we collected and re-examined all breast biopsies performed in Israel by a single pathologist (Dr. M. Black) in New York, using his prognostic grading system, nuclear differentiation and Lymphocyte Reticular Endotelial (LRE) response for benign breast diseases (BBD). The complete cohort consisted of about 3500 women. By September 1995, 460 women were traced and 349 of them were interviewed. Preliminary data show that about 42% of these women went through a second biopsy and 22% went through >2 biopsies. The latter pathological slides were sent to Dr. Black in the U.S. for re-evaluation. First follow-up for morbidity and mortality was done by linkage of our file with that of the Cancer Registry 2.2% of women with normotypic (grade 1), 3.3% of hyperplastic (grade 2), and 9% of atypic, precancerous mastopathy (grade 3-4) developed breast cancer (BC). Mortality of the cancer patients in the cohort was 38% for in-situ BC and for 67.2% invasive BC. A second stage of this study i.e. a nested case control study of the BBD cohort, using a questionnaire with complete hormonal and parity history as well as personal and family history as well as personal and family history of benign and malignant BC, physical activity and alcohol drinking habits, is on the way.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1995
- Accession Number
- ADA313425
Entities
People
- Baruch Modan