A Hierarchy of Model Systems for Biomaterials Interfaces: Analysis by Electron, Ion and Vibrational Spectroscopies.
Abstract
An obvious approach in surface analytical chemistry is to ask questions which involve developing an understanding of information for qualitative and quantitative analysis. A third important area unique to surface analysis is the description of the sampling depth of the method. Understanding the limits of imaging technologies also is important. The goal from this work is to evolve to the application of static SIMS to real polymer surfaces, to determine structure and reactivity and develop surface structure-property relationships. The major focus of this paper will be the most recent results from the development of static Time of Flight SIMS. Three results are particularly promising in the analysis of molecular biomaterials presented in this paper. (1) ToF-SIMS has allowed the sequencing of covalently bound minimal peptide sequences at fluoropolymer surfaces for neural cell adhesion applications. (2) Polymer tertiary structures, such as double helices (produced by LBK films of iso-PMMA) and alpha helices or Beta-sheet conformations can yield different ion formation mechanisms in polymer ion formation, may yield a means to identify the tertiary structure of adsorbed biomacromolecules. (3) The kinetics of surface degradation from biodegradable polymer biomaterials can be followed by oligomeric ion distributions yielded from ToF-SIMS analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1996
- Accession Number
- ADA313854
Entities
People
- J. A. Gardella Jr.
Organizations
- University at Buffalo