The Genetic Analysis of the Role of Neu Differentiation Factor (Heregulin) in Neu-Induced Mammary Carcinomas in the Mouse.

Abstract

We are investigating the need for cooperating genes in the development of ErbB2-induced mammary tumors using the mouse as a model system. In one set of experiments, we are investigating the role of ligands for the ErbB family of tyrosine kinase receptors, specifically focusing on NDF. Using a transgenic approach, we are investigating the effect of different NDF isoforms and mutant NDFs on ErbB2-induced tumors in the mouse. In a second set of experiments, hypomorphic alleles are being created at NDF, to determine the contribution of this gene in ErbB2-induced tumors. Finally, in a wider screen to identify genes that can cooperate in ErbB2-induced mammary carcinogenesis, we are performing MMTV-mutagenesis in ErbB2 transgenics to activate and tag cooperating oncogenes, with the goal of isolating and characterizing these genes.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1996
Accession Number
ADA314521

Entities

People

  • Archibald S Perkins

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Breast Cancer
  • Cells
  • Chemical Compounds
  • Chemistry
  • Culture Techniques
  • Families (Human)
  • Genes
  • Genetically Modified Organisms
  • Genetics
  • Growth Factors
  • Laboratory Animals
  • Mammary Glands
  • Materials
  • Neoplasms
  • Stem Cells

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology