Program for Critical Technologies in Breast Oncology.
Abstract
The description of work accomplished is presented under five headings: (1) collection of samples; (2) establishment of a database; (3) preparation and distribution of samples; (4) development of assays relevant to breast cancer; and (5) supplemental activities. (1) We have established protocols for collection and utilization of tissues at Yale and at fourteen off-site hospitals. We also have initiated or obtained IRB approval in all sites, and have trained/are training technical personnel. (2) We are implementing the database proposed in the original application. In addition, we have initiated a data exchange program with the Yale Cancer Center, Yale-New Haven Hospital, and the Yale Tumor Registry. (3) We have collected in the past year a total of 3754 samples of breast tissues from 1016 cases. We have distributed 8335 tissue-derived products to investigators. (4) We have developed assays to assess the status of pS3, Ki-ras, cyclin D-l (PRAD), neu/erbB-2, microsatellite variability, pl6 (MTS), AP-2, human Disheveled (hDsh), phospho-neu/erbB-2 (p185), and others. (5) We participate in a working group addressing the ethical and legal issues raised by storing samples linked to medical information concerning individual patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1996
- Accession Number
- ADA315910
Entities
People
- Jose Costa
Organizations
- Yale University