New Multilabel Fluorescent Groups for Increased Sensitivity of DNA Detection.
Abstract
The long-term goals of this project are to use oligonucleotides tagged with multiple fluorescent labels as hybridization probes of specific nucleic acid sequences. We have developed novel modes of binding between designed DNA probes and target DNA or RNA sequences, and we are investigating the combination of these new binding modes with dual (or more) fluorescent labels to raise signal intensity and signal-to-noise ratios. Such probes may be useful in detection and identification of pathogen nucleic acids as well as disease-related nucleic acid sequences in humans.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADA316448
Entities
People
- Eric T. Kool
Organizations
- University of Rochester