Regulation of Anchorage-Independent Growth in Breast Cancer: Role of Signalling by Extracellular Matrix and Growth Factors.

Abstract

Our main goal is to better understand the mechanisms by which extracellular matrix and growth factors can promote anchorage-independent growth of a murine mammary carcinoma cell line. Our objectives are to investigate: (l) (a) the role of fibronectin and the alpha 5 Beta 1 integrin in SP1 cell survival as well as, (b) the phosphorylation status of FAK under anchorage independent conditions; (2) the role of HGF and TGF-Beta in SP1 mediated cell survival; (3) and the role of PI 3-kinase in SP1 cell survival and anchorage-independent growth.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1996
Accession Number
ADA319343

Entities

People

  • Ron Saulnier

Organizations

  • Queen's University

Tags

DTIC Thesaurus Topics

  • Additives (Chemicals)
  • Adhesion
  • Amino Acids
  • Antibodies
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Growth Factors
  • Integrins
  • Kinases
  • Molecules
  • Neoplasms
  • Proteins
  • Tyrosine

Readers

  • Microbial Pathology
  • Molecular Biology and Genetics