Extrathalamic Modulation of Cortical Responsiveness.
Abstract
The overall goal of the proposed studies was to further elucidate the mechanisms by which the brainstem noradrenergic (NA) nucleus, locus coeruleus (LC), is capable of altering forebrain electrophysiological activity. The proposed studies had the following Specific Aims: (1) To examine the relationship between the intensity of LC neuronal activity, forebrain EEG activation, and rates of NA release in neocortex and hippocampus using microdialysis; (2) To test the hypothesis that LC-induced activation of forebrain EEG is mediated by LC/NA actions on septal and basal forebrain neurons; (3) To examine, in unanesthetized monkey, the effects of activating or inactivating the LC/NA system on forebrain EEG and on dialysis measures of NA and acetylcholine release in neocortex and hippocampus. The effects on these dialysis measures of systemic adrenergic drugs that alter cognitive performance was to be determined; (4) To examine, in monkey, the effects of activating or inactivating the LC/NA system on cortical and hippocampal EEG measures and on complex, bimanual motor behavior.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 17, 1996
- Accession Number
- ADA319641
Entities
People
- Stephen L. Foote
Organizations
- University of California, San Diego