Poliovirus Tumor Vaccine for Breast Cancer Micro-Metastases.
Abstract
The underlying reason for failure to cure patients diagnosed with breast cancer is the presence of micrometastases. The stimulation of anti-tumor immune responses represents one of the most effective ways to treat low tumor burdens that are microscopically or clinically occult. The objective of our proposal is to determine whether a poliovirus replicon vaccine strategy engineered to express human CEA or the HER2/neu oncogene can induce systemic immunity and eradication of micrometastases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1996
- Accession Number
- ADA319732
Entities
People
- Casey D. Morrow
Organizations
- University of Alabama