Isolation of a Receptor for WNT/Wingless Growth Factors.

Abstract

The work done in this grant aims at elucidating the function of the Wnt signaling molecules in cancer. Wnt proteins are secreted and play important roles in the control over growth, in particular in the mammary gland. Wnt genes can also can act as oncogenes in mouse mammary tumors. The work is specifically aimed at identifying a receptor for Wnt proteins. The isolation of a receptor is critical to our understanding of the mechanism of action of Wnt proteins. Using genetic and biochemical approaches we wish to identify and to clone the receptor for a Wnt gene product in Drosophila, called wingless. The receptor will be characterized and using the receptor gene, we will subsequently clone mammalian Wnt receptors by homology. During the past year, we have accomplished this goal, as a receptor for wingless has been identified.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1996
Accession Number
ADA319774

Entities

People

  • Roel Nusse

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Animal Structures
  • Animals
  • Biological Factors
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Chromosomes
  • Genetic Code
  • Genetic Structures
  • Genetics
  • Growth Factors
  • Microscopes
  • Nervous System
  • Proteins

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology