Normal and Ischemic Myocardial Transport Kinetics for Bis(N-ethoxy, N-ethyl Dithiocarbamato) Ditrido Technetium-99m (NOET).
Abstract
Recently a new Tc-99m labeled compound bis(N-ethoxy, N-ethyl dithiocarbamato) nitrido Tc-99m, or NOET, has been designed to evaluate regional myocardial blood flow and cellular viability. Previous studies of NOET indicate that it has the potential for use as a perfusion agent for assessing myocardial viability. These studies however were not designed to evaluate the actual kinetics of this agent. In the present study, Thermoluminscent Dosimeter (TLD) analysis was used in a rabbit model to assess the transport kinetics of NOET in normal and ischemic myocardium. The final rate constants for clearance in the normal and ischemic regions were 7.58E-4 + or - 1.1E-4 (1sigma) minutes-1 and 9.59E-4 + or - 3.6E-4 (1sigma) minutes-1, respectively. These compare to the arterial clearance rate constant of 4.81E-3 + or - 1.2E-3 (1sigma) minutes-1. Therefore, findings indicate that NOET has the potential to assess myocardial viability.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 09, 1997
- Accession Number
- ADA320200
Entities
People
- Terrance A. Harms
Organizations
- Air Force Institute of Technology