Biological Applications of STM & AFM in Water/High Resolution Microscopy of Nucleoprotein Complexes in Water.
Abstract
Sample preparation methods and new instrumentation have been developed for the study of biological molecules in their native (aqueous) environment by scanning tunneling microscopy (STM) and atomic force microscopy (AFM). Information from STM is complicated by the many different electron transfer mechanisms, so structural information is difficult to obtain. However, chemical identification of certain electroactive molecules may be possible at the single molecule level. A new AFM with a magnetically-oscillated tip was used to generate images of DNA of unprecedented resolution. The DNA was imaged in-situ, spontaneously adsorbed to mica in the presence of divalent ions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1996
- Accession Number
- ADA320327
Entities
People
- S. M. Lindsay
Organizations
- Arizona State University