Mechanism of Abnormal Cell-Extracellular Matrix Interactions in Human Breast Cancer.
Abstract
In our previous annual report, we summarized the accomplishment made towards each of the three specific aims stated in the original grant proposal and we listed the corresponding manuscript and publication generated from those data. Here, we would like to reiterate the objectives of the grant proposal: to characterize the molecular mechanisms by which normal versus tumor breast cells interact with their ECM and the microenvironment, and to determine the functional significance of this interaction and to examine the role of ECM/cell signaling in turmorigenesis. Functions of classical tumor suppressor genes, both Rb and genes on chromosome 11, on the behavior of mammary epithelial cells in 3-D cultures is discussed. Future studies will focus on implementing molecular biology approaches to provide fundamental clues to the mechanisms underlying the breast tumor development.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADA321029
Entities
People
- Huei-mei Chen
Organizations
- University of California, Berkeley