Neural Responses to Injury: Prevention, Protection, and Repair. Volume 4: Neurochemical Protection of the Brain, Neural Plasticity and Repair.
Abstract
The biologically active phospholipid platelet activating factor (1-O-alkyl-sn-glycero-3- phosphocholine, PAF), a phospholipase A2 (PLA2) product, is involved in excitatory neurotransmitter (i. e. Glutamate) release and synaptic plasticity (Bazan et al. ,1993). Several physiological roles of PAF have been described, such as its ability to stimulate PC 12 cell sprouting when present at low concentrations (Kornecki and Ehrlich, 1988), its stimulatory effect on glutamate release (Clark et al., 1992), and its involvement in the development of glutamate-mediated long-term potentiation (Del Cerro et al., 1990; Arai and Lynch, 1992; Wieraszko et al., 1993; Bazan et al., 1993), considered as a model of mechanisms underlying memory and learning in the brain (Teyler and DiScenna, 1984). As a consequence of neuronal cell injury, processes that normally modulate synaptic function are overactivated, leading to the accumulation of membrane lipid-derived second messengers such as 20:4 and PAF. These mediators of the cellular response to injury can lead to repair and/or to further cell damage and death (Bazan, 1994), depending upon their cellular origin and degree of neuronal activity impairment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1995
- Accession Number
- ADA321553
Entities
People
- Nicolas G Bazan
Organizations
- LSU Health Sciences Center New Orleans