Estrogen Responsive Breast Cancer Growth Regulation.
Abstract
The overall goal of this program was to characterize the serum factor(s) which regulated steroid hormone dependent human breast cancer cell growth. This included an identification of the molecule(s) and studies to establish the endocrine physiology of the regulator(s) as well as partial characterization of the receptors mediating serum factor action. We have discovered that two plasma glycoproteins, SHBG Type II and CBG, are negative regulators (i. e. inhibitors) of estrogen receptor positive (ER+) and progesterone receptor positive (PR+) breast cancer cell growth, respectively, and that autonomous (ER- and PR-) breast cancer cells are not inhibited by these glycoproteins. The new form of sex hormone binding globulin has been designated SHBG Type II. It has not previously been identified or characterized from any source. The discovery of a new regulatory role for CBG in breast cancer growth may provide our first molecular link between increased stress and an elevated risk of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADA321776
Entities
People
- David A. Sirbasku
Organizations
- University of Texas Health Science Center at Houston