Improvement of Cultured Keratinocyte Grafts for Burn Wounds.

Abstract

During the first year of grant support all components in the Statement of Work scheduled for year one have been completed, with one still in progress. The results have demonstrated that cultured keratinocyte allografts are less immunogenic in burned animals as measured by priming for second-set rejection and cytotoxic lymphocytes. Burn injury impairs expression of alloantigen on keratinocyte allograft as one mechanism of this effect. A second mechanism that effects the response is an increase in cytokine in the burn wound and distant normal tissue after burn injury. Notably, cultured keratinocyte allografts deficient in Class II histocompatability antigen are significantly less immunogenic, especially after burn injury, and may provide a means to produce universal donor keratinocytes.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1997
Accession Number
ADA321915

Entities

People

  • Anthony A. Meyer

Organizations

  • University of North Carolina at Chapel Hill

Tags

DTIC Thesaurus Topics

  • Antigens
  • Bandages
  • Biological Factors
  • Burns
  • Cells
  • Chemistry
  • Connective Tissue
  • Culture Techniques
  • Cultured Cells
  • Epithelial Cells
  • Genetic Engineering
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Peptide Growth Factors
  • Peptides
  • Proteins

Fields of Study

  • Medicine

Readers

  • Immunology
  • Trauma Surgery or Emergency Medicine.