Cyclic AMP Modulation of Estrogen-Induced Effects: A Novel Mechanism for Hormonal Resistance in Breast Cancer.

Abstract

This research is aimed at elucidating why breast cancer cells become resistant to antiestrogen treatment. Antiestrogens are used widely in the treatment of breast cancer, but development of resistance and patient relapse is a significant problem. The antiestrogen tamoxifen is the most widely prescribed drug for breast cancer treatment and it is usually considered the treatment of choice for the endocrine therapy of breast cancer because of its effectiveness, ease of use, and minimal side effects. In these studies we are using several model human breast cancer cell systems that differ in their sensitivity and resistance to tamoxifen, and we are investigating a novel mechanism and hypothesis that may explain antiestrogen resistance, namely the stimulation of adenylate cyclase by antiestrogens with increases in intracellular cAMP, augmentation of antiestrogen agonist character, and reduced effectiveness of antiestrogens as estrogen antagonists.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1996
Accession Number
ADA322200

Entities

People

  • Benita Katzenellenbogen

Organizations

  • University of Illinois Urbana–Champaign

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Culture Media
  • Enzyme Inhibitors
  • Growth Factors
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Three Dimensional

Readers

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  • Oncology
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