Defining the Smallest Common Region of Chromosome 17p that is Deleted in Sporadic Breast Tumors.
Abstract
Germline mutations in breast cancer susceptibility genes account for 8% of all breast cancer cases. BRCA1 on 17q12 and BRCA2 on 13q12-13 are implicated in 50%-60% of breast cancer families, and they are both likely to also have an impact in sporadic breast cancer cases. Recently defined loci on chromosome 8p 12-22 are frequently lost in sporadic breast cancers and there is evidence for families with linkage to these loci. We propose to ascertain 8 ethically diverse (non-Caucasian) families linked to putative BRCA3 loci on chromosome 8p, and to investigate whether a recently isolated prostate cancer metastases suppressor gene, KAII, is involved in the genetic alterations of inflammatory breast cancer, a particularly aggressive form of breast cancer which accounts for 15% of all cases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADA322215
Entities
People
- Max S. Wicha
- Sofia D Merajver
Organizations
- University of Michigan