Role of Accessory Molecule(s) in Endotoxin-Endothelial Interactions and Endothelial Barrier Dysfunction.
Abstract
This grant has been renegotiated and the new technical objectives are: (1) To determine whether LPS induces tyrosine phosphorylation of endothelial cell proteins that can be coupled to changes in barrier function. (2) To determine whether this LPS-induced endothelial intercellular gap formation and barrier dysfunction is due to zonula adherens and/or focal adhesion disassembly. (3) To determine which protein substrates are the targets of LPS-induced tyrosine phosphorylation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1996
- Accession Number
- ADA322233
Entities
People
- Simson E. Goldblum
Organizations
- University of Maryland School of Medicine