Protein Kinase C Isozyme in Mammary Carcinogenesis.

Abstract

Protein kinase C (PKC) is a key signal transduction pathway for regulating cell growth and differentiation. Perturbations in the PKC signaling pathway are widely recognized to be important in carcinogenesis since PKCs are the major cellular receptors for tumor promoting phorbol esters. PKC is actually a family of distinct isozymes that catalyze phospholipid-dependent protein phosphorylation. The role of individual isozymes in cellular processes has not yet been defined. The goal of this proposal is to study the role of individual PKCs in regulating mammary tumor growth and metastatic conversion.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1996
Accession Number
ADA322234

Entities

People

  • Susan Jaken

Organizations

  • The W. Alton Jones Cell Science Center

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Culture Techniques
  • Cultured Cells
  • Epithelial Cells
  • Kinases
  • Materials
  • Medical Personnel
  • Neoplasms

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular Biology and Genetics
  • Molecular and Cellular Biochemistry