The Role of Heparin-Binding EGF-Like Growth Factor in Breast Cancer

Abstract

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family which binds to and activates the EGF receptor. Its role in breast cancer, however, is unclear. We have studied the regulation of HB-EGF expression in nontransformed and transformed mammary epithelial cells. HB-EGF is induced by 12-0- tetradecanoylphorbol- 13-acetate (TPA) in most of the cell lines analyzed. In contrast with transforming growth factor alpha or amphiregulin, HB-EGF is not induced by estrogen or progesterone in any of the estrogen responsive, estrogen receptor positive breast cancer cell lines examined. HB-EGF RNA levels are induced by EG-related peptides in the spontaneously immortalized mammary epithelial cell line.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1996
Accession Number
ADA322376

Entities

People

  • David S. Salomon

Organizations

  • National Institutes of Health

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Culture Media
  • Epithelial Cells
  • Growth Factors
  • Mammary Glands
  • Mrna
  • Neoplasms
  • Peptide Growth Factors
  • Proteins
  • Ribonucleic Acids

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics