Genetic Abnormalities in Breast Cancer Tumors and Relationships to Environmental and Genetic Risk Factors Using Twins.
Abstract
Little is known about factors that produce genetic abnormalities in breast tumors; germline mutations explain only a few cases. Specifically we will address the following issues in this study: (1) Are genetically similar tumors more likely to occur among identical twins than among fraternal twins?; (2) Do environmental factors predispose to concordance or discordance of genetic abnormalities?; (3) Do fraternal twins, concordant for environmental exposures, tend to be discordant for genetic abnormalities, suggesting that other predisposing genetic factors that can be identified?; (4) Among identical twins discordant for disease, are specific environmental factors more related to tumors with a genetic abnormality than those without?
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADA323648
Entities
People
- Thomas M. Mack
Organizations
- University of Southern California