Cell-Matrix Interactions in Breast Cancer Cells.
Abstract
Modulation in adhesion of tumor cells compared with their normal counterparts plays an important role in development of invasive potential. Our application, as funded, concerns the fate of certain epithelial cell-matrix connectors called hemidesmosomes which are involved in anchoring breast epithelial cells to underlying matrix. The following were the set of tasks funded by the US Army in 1994. Task (1) Immunochemical characterization of hemidesmosome components in normal and tumor breast tissue and their cultured cell counterparts Task (2) Molecular analyses where message levels of HD proteins will be determined (complimentary to task 1). Task (3) Electron microscopic evaluation of normal and tumor material Task (4) Cell assays in matrigel
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1996
- Accession Number
- ADA323762
Entities
People
- Jonathan C. Jones
Organizations
- Northwestern University