Breast Cancer Metastasis: Prognosis and Monitoring of Metastatic Disease.
Abstract
During the past several years we have conducted extensive studies on the role of degradative enzymes in the invasion and metastasis of breast cancers. We found that only a few enzymes were implicated in the invasion of human breast cancer cells, such as heparanase and type IV collagenolytic metalloproteinases. The major purposes of the proposal are: (1) Develop prognostic tests for breast cancer invasion and metastasis-associated degradative enzymes. (2) Develop assays to monitor the appearance of metastatic disease in breast cancer patients by detecting the appearance of metastasis- associated degradative enzymes in blood. (3) Develop assays to monitor the treatment of metastatic disease in breast cancer patients by following the levels of metastasis- associated degradative enzymes in blood.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADA323763
Entities
People
- Douglas Boyd
Organizations
- The University of Texas MD Anderson Cancer Center