The Effect of Intramedullary Polymethylmethacrylate and Autogenous Cancellous Bone on Healing of Frozen Segmental Allografts,

Abstract

This study was designed to compare limb function, bone mineral density, periosteal callus, new bone, porosity, histology, and union of mid-diaphyseal segmental allografts of the femur stabilized with an interlocking nail (ILN) technique in a dog model. An in vivo study was performed to compare the effects of augmenting ILN fixation with the following: ILN alone (n), ILN plus intramedullary cement (nc), ILN plus intramedullary cement and autogenous cancellous bone applied to the periosteal surface of the host-allograft junction (ncp), ILN plus autogenous cancellous bone applied to the endosteal surface of the allograft (ne), ILN plus autogenous cancellous bone applied to the periosteal surface of the host-allograft junction (np), and ILN plus autogenous cancellous bone applied to the periosteal surface of the host-allograft junction and to the endosteal surface of the allograft (npe). Following allograft implantation, the dogs were evaluated by radiography, dual energy X-ray absorptiometry, and force plate gait analysis from 0 to 24 weeks. Six months after allograft implantation, the dogs were euthanatized and the femora processed for analysis. There were no differences between treatments for limb function or bone mineral density. Callus area 4 weeks after surgery was greater along the lateral and cranial surfaces for treatments receiving periosteal cancellous bone (P<0.05). This was also evident along the caudal surface at 24 weeks (P<0.05). New bone within the allograft segment did not differ between treatments and was reduced compared to the host-allograft junctions (P<0.05). Histologic scores were greatest with treatments 'ncp' and npe', listed above (P<0.05).

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1997
Accession Number
ADA324416

Entities

People

  • Chad Warner
  • Christian Osmond
  • John J. Bogdanske
  • Peter D. Hanson
  • Rachael Kofroth

Organizations

  • University of Wisconsin Madison School of Veterinary Medicine

Tags

DTIC Thesaurus Topics

  • Algorithms
  • Allografts
  • Analysis Of Variance
  • Anti-Bacterial Agents
  • Autografts
  • Bone And Bones
  • Cartilage
  • Data Acquisition
  • Growth Factors
  • Measurement
  • Osteogenesis
  • Sites
  • Standards
  • Statistical Analysis
  • Surgery
  • Tissues
  • X Rays

Fields of Study

  • Materials science
  • Medicine

Readers

  • Immunology and Pathology
  • Neuroscience