Inhalation Uptake and Metabolism of Iodohalogenated Compounds, CF3I, C6F13I, and C3F7I.

Abstract

The purpose of this study was to measure the tissue to air partition coefficients and to describe the uptake and distribution kinetics of iodohalogenated compounds iodotrifluoromethane (CF3I), perfluorohexyl iodide (C6F13I) and l-iodoheptafluoropropane (C3F7l) via closed chamber recirculating gas uptake methods. Inhalation pharmacokinetics for all chemicals were determined experimentally in Fischer-344 (F-344) male rats. A physiologically based pharmacokinetic (PBPK) model was used to describe mathematically the disposition and metabolism of the chemicals employing chemical-specific parameters and apparent whole-body metabolic constants calculated from these expenments

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1995
Accession Number
ADA324574

Entities

People

  • B. L. Garrity
  • J. R. Creech
  • Lu Dong
  • R. Abbas
  • R. K. Black

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  • Air Force
  • Body Weight
  • Boiling Point
  • Chemistry
  • Chlorides
  • Computer Simulations
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  • Government Procurement
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  • Laboratory Animals
  • Mainframe Computers
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  • Metabolism
  • Pharmacokinetics
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  • Sodium Hydroxide

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  • Organic Chemistry
  • Toxicology/Environmental Toxicology