Developmental Toxicity Screen of Ammonium Perchlorate Using Hydra attenuata.

Abstract

Ammonium perchlorate (AP) is an oxidizer used as a component in solid rocket propellants, munitions and fireworks. An in vitro developmental toxicity screen was performed to determine the developmental hazard index (A/D ratio) for AP using the hydra assay. Hydra attenuata have the capability for whole body regeneration. The assay employs exposing both adult hydra and 'artificial embryos' composed of disassociated hydra cells to test compounds to investigate developmental toxicity. Results from the hydra assay of AP indicated the minimal effective concentration required to elicit a toxic response in the adult hydra and in the regenerating hydra were 600 mg A/L and 350 mg AP/L, respectively. The A/D ratio of 1.71 determined that AP should not be considered a primary developmental toxin in the context of this assay.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1996
Accession Number
ADA324780

Entities

People

  • E. R. Kinkead
  • P. D. Confer
  • R. E. Wolfe

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acid-Base Indicators
  • Air Force
  • Ammonium Perchlorate
  • Contracts
  • Department Of Defense
  • Diseases And Disorders
  • Endocrine Glands
  • Government Procurement
  • Governments
  • Perchlorates
  • Propellants
  • Solid Rocket Oxidizers
  • Solid Rocket Propellants
  • Thyroid Therapy Drugs
  • United States
  • United States Government
  • Water

Readers

  • Neuroscience
  • Parallel and Distributed Computing.
  • Rocket Propulsion.