Mechanisms Associated with the Toxicity of Polyhalogenated Cyclic Hydrocarbons and Heavy Metals.
Abstract
We have hypothesize that the toxic manifestations of polyhalogenated cyclic hydrocarbons and heavy metals are at least in part induced through a series of events involving the production of reactive oxygen species, activation of the protein kinase C system and release of tumor necrosis factor-a (TNFa). The sequence of these events is not known, and the relationship between these events and the induction of stress protein has not been studied. Both in vivo and in vitro effects on these parameters as well as acute and chronic studies will be determined. The above hypothesis will be tested by completing the following specific aims. Excellent progress has been made relative to the specific objectives of this research project. Based on the results which have been completed during the past three years, 21 manuscripts were published or are in press in refereed journals, and 14 presentations have been made at national and international scholarly meetings.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADA325697
Entities
People
- Sidney J. Stobs
Organizations
- Creighton University