Studies on the Mechanism of Action of the in vitro PGBx Effect: IV - The Effect of Order of Addition of PGBx to Assay System,

Abstract

The mechanism of action of PGBx in RLM oxidative phosphorylation was studied by varying the sequence of addition of PGBx. When PGBx was added to RLM preexposed to hypotonic media at 270 no restoration of phosphorylation was observed, When RLM were exposed to hypotonic conditions for 30 seconds before the addition of PGBx and subsequently exposed to hypotonic conditions, the resulting phos- phorylation was 60% of that observed in the normal system. From these results it is concluded that PGBx functions in the in vitro PGBx RLM assay system as a 'protective' agent rather than a restorative agent.

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Document Details

Document Type
Technical Report
Publication Date
Oct 16, 1981
Accession Number
ADA325784

Entities

People

  • Herman W. Shmukler
  • Margaret G. Zawryt

Organizations

  • Naval Air Warfare Center Warminster

Tags

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  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Biochemistry
  • Chemical Compounds
  • Chemistry
  • Classification
  • Engineering
  • Materials
  • Mathematics
  • Military Research
  • Mitochondria
  • Numbering Systems
  • Numbers
  • Phosphorylation
  • Reaction Time
  • Security
  • Sequences

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  • Battery Technology and Engineering
  • Cellular and Molecular Pathways of Apoptosis.
  • Naval Engineering and Maritime Security