Splicing Variants of Estrogen Receptor in Breast Cancer.

Abstract

Work continued on a systematic analysis of the abundance of estrogen receptor mRNA splicing variants in several human breast tumor specimens. Plasmid vectors have been developed to allow the expression of these variant receptor proteins and to enable characterization of their function. Results have been obtained with respect to stability of expression, DNA-binding activity, subcellular localization, and transcriptional activity of each of six exon-skipped receptor variants.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1996
Accession Number
ADA325785

Entities

People

  • Richard J. Miksicek

Organizations

  • State University of New York

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Culture Techniques
  • Cultured Cells
  • Epithelial Cells
  • Estrogens
  • Gene Expression
  • Hormones
  • Materials
  • Medical Personnel
  • Neoplasms
  • New York
  • Polymerase Chain Reaction
  • Tumor Cell Line
  • Universities

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Molecular and genetic basis of cancer.