Epidermal Growth Factor-Like Ligands in Breast Cancer.
Abstract
Cripto-1 (Cr-1) and Amphiregulin (Ar) are two EGF-like growth factors that occur at higher levels in breast cancer cells and tissues. We have shown that they occur in the late stages of mammary cell proliferation in virgin, pregnant and lactating mouse mammary glands. in order to test the roles of Cr-1, we infected CID9 normal mouse mammary cells with retroviruses over-expressing Cr-1, or with retroviruses that express an antisense version, in order to inhibit the production of this Polypepide.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1996
- Accession Number
- ADA325824
Entities
People
- Eileen D. Adamson
Organizations
- Sanford Burnham Prebys Medical Discovery Institute