Cell-Cell Adhesion and Breast Cancer.
Abstract
The objective of this proposal is to elucidate the role of cell-cell adhesion and calcium dependent cell adhesion molecules cadherins in breast tumor progression. We will test the hypothesis that in addition to the occasional loss of E-cadherin expression, breast tumor progression is more realistically modeled by a loss of strong cell-cell adhesion resulting from defects in any one or more of the steps (molecules) required for E-cadherin function. During the past year we have used biophysical techniques to measure cell-cell adhesive strength Serine phosphorylation of Beta 3-catenin was found to regulate protein stability in a pathway involving the tumor suppressor gene APC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1997
- Accession Number
- ADA325834
Entities
People
- Stephen W. Byers
Organizations
- Georgetown University