TGFa-myc Interactions in Mammary Tumorigenesis.

Abstract

The goals our project were twofold. First, we were to characterize rapid onset bitransgenic TGF alpha-Myc mouse mammary tumors for expression of sex steroid receptors and for indicators of epithelial differentiation status. Second, we were to characterize tumors for amplification of genes encoding TGF alpha, c-Myc, EGF receptor, the Myc protein partner Myn, and for expression or relevant cyclins.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1996
Accession Number
ADA325990

Entities

People

  • Robert B. Dickson

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Antigens
  • Apoptosis
  • Biological Factors
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Dermatologic Agents
  • Epithelial Cells
  • Growth Factors
  • Neoplasms
  • Parotid Glands
  • Programmed Cell Death
  • Proteins
  • Salivary Glands

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics