Role of Matrix Metalloproteinases and Their Tissue Inhibitors in Human Breast Adenocarcinoma.
Abstract
The overall objective of this research is to explore the role of matrix metalloproteinases (MMPs) and the tissue inhibitors of metal- loproteinases (TIMPs) in the invasive and metastatic processes of human breast tumors. The hypothesis to be tested is that an imbalance arises through normal or elevated production of MMPs accompanied by a diminished production of inhibitory TIMPs. Metastasis of an initially localized tumor to vital organs is the dominant cause of cancer related deaths.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1996
- Accession Number
- ADA326012
Entities
People
- Zeenat Gunja-smith
Organizations
- University of Miami