Line-i Retrotransposons as Mutagens in Human Breast Cancer.
Abstract
Our long range goals focus on the isolation of cellular genes that are affected by LlHs transposition. These genes are presumably the ones whose inactivation (by insertional mutagenesis), or activation (by readthrough transcription), is one of the steps in the pathway leading to malignancy. Specifically we have proposed to: (1) Place a 'tagged', transpositionally competent LlHs element into non-malignant human breast epithelial cells. (2) Identify malignant cells arising from the non-malignant cell population and isolate and characterize sequences into which the tagged LlHs element has transposed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADA326065
Entities
People
- Thomas G. Fanning
Organizations
- Armed Forces Institute of Pathology