Regulation of Breast Cancer Invasion and Metastasis by Progestin and Antiprogestin.

Abstract

It is known that breast cancer is dependent upon estrogenic hormones in about one-third of all clinical cases and can be inhibited by antiestrogenic antagonists. We are now hypothesizing that progestational hormones may also function as a stimulus for onset and progression of breast cancer and antiprogestin can interrupt these processes. Antiestrogen tomaxifen treatment enhances the progestational stimulation of tumor growth. Mammary derived growth inhibitor (MDGI) is a mammary epithelial cell growth inhibitor and differentiation factor.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1996
Accession Number
ADA327079

Entities

People

  • Yuenian E. Shi

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Breast Cancer
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Dna Sequence Analysis
  • Epithelial Cells
  • Health Services
  • Medical Personnel
  • Peptide Growth Factors
  • Peptides
  • Proteins

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.