Initiation of Breast Cancer by Endogenous Estrogens: Mechanism and Prevention.

Abstract

Both endogenous and environmental factors are thought to contribute to cancer of the breast. Among these, estrogens have attracted intense interest for decades, but the mechanisms by which this class of hormone mediate normal and neoplastic growth have remained obscure. We provide in vitro data to support the hypothesis that 16 alpha-hydroxyestrone is unique among estrogens with regard to its transforming properties in mammary cells.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1997
Accession Number
ADA327101

Entities

People

  • Jack Fishman

Organizations

  • Weill Cornell Medicine

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Culture Techniques
  • Epithelial Cells
  • Estrogens
  • Genes
  • Genetics
  • Glands
  • Hormones
  • Identification
  • Mammary Glands
  • Metabolism
  • Neoplasms
  • Tumor Cell Line

Readers

  • Educational Psychology
  • Molecular Biology and Genetics