The Development and Application of Cellular Sensitivity Biomarkers for the Detection and Measurement of Toxic Effects in Normal and Malignant Cells from Patients Receiving High-Dose Melphalan with Autologous Peripheral Blood Progenitor Cell Rescue in the Treatment of Metastic Breast Cancer.

Abstract

This study provides an extraordinary setting for applying biomarkers of cellular sensitivity to monitor and analyze therapeutic versus toxic effects in cancer chemotherapy. The difference between delivered and biologically effective doses of a drug is the consequence of many complex interacting factors. These include: absorption, cellular uptake, distribution, affinity for intended target tissue and excretion capacities; outcome of metabolic activation processes; ability to repair damage and levels of cofactors that modify drug action.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1997
Accession Number
ADA327144

Entities

People

  • Atif M. Hussein
  • James J. Vredenburgh
  • William P. Peters

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Blood
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Clinical Trials
  • Databases
  • Detection
  • Drug Resistance
  • Information Science
  • Lymphocytes
  • Neoplasms
  • Resistance
  • Statistical Analysis
  • Stem Cells
  • Test Methods
  • Tumor Cell Line

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Oncology (Cancer Research).