The Development of an Effective Vaccine, Post Exposure Prophylaxis and for Prevention and Control of AIDS.
Abstract
Studies undertaken in Year 2 of Grant DAMD 17-95-1-5031 focused on induction of complementary immune responses including neutralizing antibodies, mucosal immunity and cytotoxic T cells likely to be necessary for development of long-term protective immunity against IV infection and AIDS. Preclinical studies of DNA plasmid immunogens expressing MIV antigens and immunostimulatory cytokines for priming of cellular immune responses followed by subunit peptide immunogens for boosting humoral immunity provided a strategy for maximizing immune effector mechanisms. Similarly, preclinical studies utilizing systemic priming followed by mucosal boosting provided a strategy for addressing differential routes of HIV transmission. Finally, monoclonal antibodies previously identified with potent anti-HIV efficacy, demonstrated their ability to be effective in post-exposure prophylaxis studies, and synthetic immunogens are currently being evaluated to mimic to efficacy of these potent monoclonals.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1997
- Accession Number
- ADA327374
Entities
People
- Wayne C. Koff