Vitamin D3 Analogues with Low Vitamin D Receptor Binding Affinity Regulate Chondrocyte Proliferation, Proteoglycan Synthesis, and Protein Kinase C Activity

Abstract

The purpose of the study was to determine the genomic and nongenomic mechanism of action of various analogues of vitamin D on resting zone (RC) and growth zone (GC) rat costochondral chondrocyte differentiation and proliferation in vitro. This study is intended to provide insight into how modifications of the A-ring and other structural modifications of vitamin D molecule affect the biological activity of these secosteroids.

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Document Details

Document Type
Technical Report
Publication Date
Jul 11, 1997
Accession Number
ADA327924

Entities

People

  • Daniel M. Greising

Organizations

  • Air Force Institute of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Blood
  • Bone And Bones
  • Bone Diseases
  • Breast Cancer
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Connective Tissue
  • Lymphocytes
  • Metabolic Diseases
  • Nutrition Disorders
  • Osteogenesis
  • Skin Diseases
  • Two Dimensional
  • Vitamin D

Readers

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