Genetic Alterations in Familial Breast Cancer: Mapping and Cloning Genes Other than BRCA1.
Abstract
The purpose of this project is to identify genes responsible for inherited susceptibility to breast cancer in families. Two such genes have been cloned (BRCA1 and BRCA2), but the existence of families with many cases of breast cancer but no mutations in these genes suggests that other BRCA genes may exist. Using an integrated approach involving dissection of germline chromosomal rearrangements in women with very early onset breast cancer, coupled with linkage analysis in families, we are cloning the gene on chromosome 10q responsible for Cowden disease and possibly for breast cancer in the absence of other Cowden symptoms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1996
- Accession Number
- ADA328004
Entities
People
- Mary-claire King
- Warren Winkelstein Jr
Organizations
- University of California, Berkeley