Transgenic Analysis of the Role of Transcription Factor AP-2 in Breast Development and Breast Cancer.

Abstract

One of the most alterations in human breast cancer is the overexpression of the c-erbB-2 protooncogene that has been shown to occur in 25-30% of human breast tumors. Recently this increased expression has been shown to correlate with the presence of the transcription factor AP-2. We have begun to determine the role of AP-2 both in normal mammary gland development and in breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1997
Accession Number
ADA328032

Entities

People

  • Jian Zhang

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Alkanes
  • Amino Acids
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Gene Expression
  • Mammary Glands
  • Molecules
  • Neoplasms
  • Peptides
  • Proteins
  • Transcription Factors
  • Tumor Cell Line

Fields of Study

  • Medicine

Readers

  • Marine Ecotoxicology
  • Molecular Biology and Genetics