Acute Toxicity Evaluation of a New Noncorrosive Decontamination Solution.
Abstract
U.S. Navy requested evaluation of a new noncorrosive chemical warfare decontamination solution (NDS) designed for removal of toxic chemicals from equipment. This investigation contained three experiments: acute oral limit test, acute dermal limit test, and acute inhalation limit test. Oral gavage with 5 g NDS/kg resulted in 100% mortality of male and female F-344 rats. Clinical signs included whole body tremors and chromodacryorrhea. Treatment at lower oral concentrations of NDS resulted in the determination of an LD50 at 0.78 g/kg. All male and female NZW rabbits died after dermal treatment with 2 g NDS/kg. Signs of toxicity prior to death included whole body tremors and excessive salivation. Dermal treatment at lower doses of NDS resulted in the determination of a dermal LD50 of 0.36 g/kg. Inhalation exposure of male and female rats to near the limit test concentration (4.4 mg/L) also resulted in 100% mortality. The 4-h LC50 for NDS aerosol was determined to be 1.36 mg/L. The 100% fatality associated with the higher levels of exposure for all routes of exposure, coupled with a lack of significant gross or histologic lesions, suggests that deaths were not necessarily due to corrosive action. Additional studies would be required to explain the cause(s) of mortality following administration of NDS.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1997
- Accession Number
- ADA328038
Entities
People
- David H Ellis
- Harry F. Leahy
- Marcia L. Feldmann
- Patrick M. Callaghan
- Robin E. Wolfe