Effect of Levonorgestrel (NORPLANT) on the Immune Regulation of Bone Morphogenesis in Calvarial Cultures from the Laboratory Mouse (Mus muscularis).
Abstract
Steroid sex hormones such as estrogen and progesterone affect gingival and osseous tissues and can mediate cytokine production. When administered as oral contraceptives, these hormones affect bone morphogenesis and mediate periodontal disease. Norplant, the subdermal contraceptive implant, continually releases a synthetic progestin, levonorgestrel, for five years. In order to assess the impact of levonorgestrel on bone cells, murine calvarial cell cultures were harvested, grown to confluence and treated with levonorgestrel, progesterone and estrogen. The majority of the cells grown in these bone cell cultures were phenotypically and morphologically characteristic of an osteoblast.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1995
- Accession Number
- ADA328398
Entities
People
- Arlynn G. Raez
- Carol A. Lapp
- David W. Craft