Amino Acid Sequence Transfer Operators and Metric Space Distortions of Proteins,
Abstract
Physical and chemical studies of protein dynamics often yield nonlinear distortions and multiplicities of time scales which are partially resolved via scaling solutions. Assuming that the internal basis of the metric relations of proteins is hydrophobic hydration. we demonstrate a relationship between an expanding group action on hydrophobic amino acid sequences and the fractional spatial scalings of amino acid monomeric mass distances in 25 representative proteins. This empirical relationship is analogous to that resulting from the tessellation of non-Euclidean spaces by discrete groups and suggests a route to physical uniformization of the data of protein dynamics without ad hoc scaling corrections.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1993
- Accession Number
- ADA328656
Entities
People
- Arnold J. Mandell
- Karen A. Selz
Organizations
- Institut des Hautes Études Scientifiques